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J Child Adolesc Psychopharmacol. 2010 Oct;20(5):441-5. doi: 10.1089/cap.2009.0097.

Rapid quetiapine loading in youths with bipolar disorder.

Author information

1
Department of Psychiatry, University of Kansas School of Medicine-Wichita, Wichita, Kansas 67214, USA. Rscheffer@kumc.edu

Abstract

OBJECTIVE:

The aim of this study was to evaluate the tolerability and efficacy of rapid quetiapine loading in youth diagnosed with pediatric bipolar disorder (PBD).

METHOD:

Quetiapine was started at 100 mg/day, and increased to 400 mg/day by day 5 in 75 bipolar children (6-16 years), presenting in an acute manic or hypomanic episode. Subsequent dose adjustments were predicated on the clinical picture. Response was defined as a ≥ 50% reduction in baseline scores on the Young Mania Rating Scale (YMRS). Clinical Global Impression-Improvement Scale (CGI-I) scores of "2 much improved" or "1 very much improved" were used as secondary measures of response. Remission was defined as a YMRS score of ≤ 12. Adverse events, blood pressure, weight change, somnolence, extrapyramidal syndrome (EPS), and akathisia were monitored to determine tolerability.

RESULTS:

At 8 weeks, 94% of the sample had a CGI-I score ≤ 2, and 70% were in remission at 6 months. Sedation was reported by 50% of subjects during the first week; this rate dropped to 5.6% at 6 months.

CONCLUSION:

The findings indicate that rapid dose administration of quetiapine in children and adolescents with PBD is generally well tolerated and efficacious.

PMID:
20973715
DOI:
10.1089/cap.2009.0097
[Indexed for MEDLINE]

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