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MAGMA. 2010 Dec;23(5-6):289-307. doi: 10.1007/s10334-010-0228-5. Epub 2010 Oct 24.

Resting developments: a review of fMRI post-processing methodologies for spontaneous brain activity.

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1
Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. margulies@cbs.mpg.de

Abstract

Analytic tools for addressing spontaneous brain activity, as acquired with fMRI during the "resting-state," have grown dramatically over the past decade. Along with each new technique, novel hypotheses about the functional organization of the brain are also available to researchers. We review six prominent categories of resting-state fMRI data analysis: seed-based functional connectivity, independent component analysis, clustering, pattern classification, graph theory, and two "local" methods. In surveying these methods, we address their underlying assumptions, methodologies, and novel applications.

PMID:
20972883
DOI:
10.1007/s10334-010-0228-5
[Indexed for MEDLINE]
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