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Curr Opin Biotechnol. 2010 Dec;21(6):834-42. doi: 10.1016/j.copbio.2010.09.018.

Bryostatins: biological context and biotechnological prospects.

Author information

1
Instituto de Química de São Carlos, Universidade de São Paulo CP 780, CEP 13560-970, São Carlos, SP, Brazil.

Abstract

Bryostatins are a family of protein kinase C modulators that have potential applications in biomedicine. Found in miniscule quantities in a small marine invertebrate, lack of supply has hampered their development. In recent years, bryostatins have been shown to have potent bioactivity in the central nervous system, an uncultivated marine bacterial symbiont has been shown to be the likely natural source of the bryostatins, the bryostatin biosynthetic genes have been identified and characterized, and bryostatin analogues with promising biological activity have been developed and tested. Challenges in the development of bryostatins for biomedical and biotechnological application include the cultivation of the bacterial symbiont and heterologous expression of bryostatin biosynthesis genes. Continued exploration of the biology as well as the symbiotic origin of the bryostatins presents promising opportunities for discovery of additional bryostatins, and new functions for bryostatins.

PMID:
20971628
PMCID:
PMC4497553
DOI:
10.1016/j.copbio.2010.09.018
[Indexed for MEDLINE]
Free PMC Article

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