Chromosome segregation: taking the passenger seat

Curr Biol. 2010 Oct 26;20(20):R879-81. doi: 10.1016/j.cub.2010.09.037.

Abstract

The chromosomal passenger complex (CPC) is a major regulator of mitotic and meiotic chromosome segregation. Three recent papers now elucidate the mechanisms that determine the localization of the CPC to the inner centromere.

MeSH terms

  • Aurora Kinases
  • Centromere / metabolism*
  • Chromosomal Proteins, Non-Histone / metabolism*
  • Chromosome Segregation / physiology*
  • Microtubule-Associated Proteins / metabolism*
  • Models, Biological
  • Multiprotein Complexes / genetics
  • Multiprotein Complexes / metabolism*
  • Phosphorylation
  • Protein Serine-Threonine Kinases / metabolism*

Substances

  • Chromosomal Proteins, Non-Histone
  • Microtubule-Associated Proteins
  • Multiprotein Complexes
  • Aurora Kinases
  • Protein Serine-Threonine Kinases