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Bioorg Med Chem Lett. 2010 Dec 1;20(23):7011-4. doi: 10.1016/j.bmcl.2010.09.121. Epub 2010 Sep 29.

Indazole derivatives as novel bradykinin B1 receptor antagonists.

Author information

1
Department of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA. vbodmer@mac.com

Abstract

A new class of indazole-derived bradykinin B(1) antagonists and their structure-activity relationships (SAR) is reported. A number of compounds were found to have low-nanomolar affinity for the human B(1) receptor and possess acceptable P-gp and pharmacokinetics properties.

PMID:
20971001
DOI:
10.1016/j.bmcl.2010.09.121
[Indexed for MEDLINE]

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