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Curr Opin Immunol. 2011 Feb;23(1):104-10. doi: 10.1016/j.coi.2010.09.009. Epub 2010 Oct 21.

Diverse roles of non-diverse molecules: MHC class Ib molecules in host defense and control of autoimmunity.

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  • 1Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, United States.


While the prime function of classical MHC class I molecules (MHC-I) is to present peptide antigens to pathogen-specific cytotoxic T cells, non-classical MHC-I antigens perform a diverse array of functions in both innate and adaptive immunity. In this review we summarize recent evidence that non classical MHC-I molecules are not only recognized by pathogen-specific T cells but that they also serve as immunoregulatory molecules by stimulating a number of distinct non-conventional T cell subsets.

Copyright © 2010 Elsevier Ltd. All rights reserved.

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