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Curr Biol. 2010 Nov 9;20(21):1900-6. doi: 10.1016/j.cub.2010.09.044. Epub 2010 Oct 21.

Sensitive period for a multimodal response in human visual motion area MT/MST.

Author information

1
Brain and Cognitive Sciences Department, Massachusetts Institute of Technology, Room 46-4021, 43 Vassar Street, room 46-4021, Cambridge, MA 02139, USA. mbedny@mit.edu

Abstract

The middle temporal complex (MT/MST) is a brain region specialized for the perception of motion in the visual modality. However, this specialization is modified by visual experience: after long-standing blindness, MT/MST responds to sound. Recent evidence also suggests that the auditory response of MT/MST is selective for motion. The developmental time course of this plasticity is not known. To test for a sensitive period in MT/MST development, we used fMRI to compare MT/MST function in congenitally blind, late-blind, and sighted adults. MT/MST responded to sound in congenitally blind adults, but not in late-blind or sighted adults, and not in an individual who lost his vision between ages of 2 and 3 years. All blind adults had reduced functional connectivity between MT/MST and other visual regions. Functional connectivity was increased between MT/MST and lateral prefrontal areas in congenitally blind relative to sighted and late-blind adults. These data suggest that early blindness affects the function of feedback projections from prefrontal cortex to MT/MST. We conclude that there is a sensitive period for visual specialization in MT/MST. During typical development, early visual experience either maintains or creates a vision-dominated response. Once established, this response profile is not altered by long-standing blindness.

PMID:
20970337
PMCID:
PMC2998392
DOI:
10.1016/j.cub.2010.09.044
[Indexed for MEDLINE]
Free PMC Article

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