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J Formos Med Assoc. 2010 Oct;109(10):736-9. doi: 10.1016/S0929-6646(10)60119-2.

Association of novelty seeking scores and striatal dopamine D₂/D₃ receptor availability of healthy volunteers: single photon emission computed tomography with ¹²³i-iodobenzamide.

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Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan; Department of Psychiatry, Tainan Municipal Hospital, 138 Shen Li Road, Tainan, Taiwan.


It has been speculated that novelty seeking (NS) behavior is related to the dopaminergic system. Fifty-two subjects completed the Tridimensional Personality Questionnaire and underwent single photon emission computed tomography with (123)I-iodobenzamide. A marginally positive correlation was noted between NS and striatal dopamine D(2)/D(3) receptor availability (r = 0.25, p =0.07). A positive association was noted between the NS scores and left striatal D(2)/D(3) receptor availability (r= 0.29, p =0.04). The results suggest that a relationship might exist between NS score and dopaminergic activity.

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