Format

Send to

Choose Destination
J Clin Aesthet Dermatol. 2009 Jan;2(1):26-30.

Rosacea, reactive oxygen species, and azelaic Acid.

Author information

1
Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts.

Abstract

Rosacea is a common skin condition thought to be primarily an inflammatory disorder. Neutrophils, in particular, have been implicated in the inflammation associated with rosacea and mediate many of their effects through the release of reactive oxygen species. Recently, the role of reactive oxygen species in the pathophysiology of rosacea has been recognized. Many effective agents for rosacea, including topical azelaic acid and topical metronidazole, have anti-inflammatory properties. in-vitro models have demonstrated the potent antioxidant effects of azelaic acid, providing a potential mechanistic explanation for its efficacy in the treatment of rosacea.

PMID:
20967185
PMCID:
PMC2958186

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center