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Science. 2010 Oct 22;330(6003):514-517. doi: 10.1126/science.1193036.

SNP genotyping defines complex gene-flow boundaries among African malaria vector mosquitoes.

Author information

1
Broad Institute, Cambridge, MA 02142, USA.
2
Imperial College London, London SW7 2AZ, UK.
3
Malaria Research and Training Center, Bamako, Mali.
4
Centre National de Recherche et Formation sur le Paludisme, Ouagadougou, Burkina Faso.
5
Institut de Recherche pour le Développement, Unité de Recherche R016, Montpellier, France.
6
Organisation de Coordination pour la Lutte contre les Endémies en Afrique Centrale, Yaounde, Cameroon.
7
University of Notre Dame, Notre Dame, IN 46556, USA.
8
Harvard School of Public Health, Boston, MA 02115, USA.
9
Boston College, Chestnut Hill, MA 02467, USA.
#
Contributed equally

Erratum in

  • Science. 2010 Dec 10;330(6010):1477.

Abstract

Mosquitoes in the Anopheles gambiae complex show rapid ecological and behavioral diversification, traits that promote malaria transmission and complicate vector control efforts. A high-density, genome-wide mosquito SNP-genotyping array allowed mapping of genomic differentiation between populations and species that exhibit varying levels of reproductive isolation. Regions near centromeres or within polymorphic inversions exhibited the greatest genetic divergence, but divergence was also observed elsewhere in the genomes. Signals of natural selection within populations were overrepresented among genomic regions that are differentiated between populations, implying that differentiation is often driven by population-specific selective events. Complex genomic differentiation among speciating vector mosquito populations implies that tools for genome-wide monitoring of population structure will prove useful for the advancement of malaria eradication.

PMID:
20966254
PMCID:
PMC4811326
DOI:
10.1126/science.1193036
[Indexed for MEDLINE]
Free PMC Article

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