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Exp Mol Pathol. 2011 Feb;90(1):74-8. doi: 10.1016/j.yexmp.2010.10.004. Epub 2010 Oct 19.

Immunological aspect of cardiac remodeling: T lymphocyte subsets in inflammation-mediated cardiac fibrosis.

Author information

1
Department of Cardiology, First Affiliated Hospital of Harbin Medical University, 150001, China. wliu4@uvm.edu

Abstract

Cardiac fibrosis is defined as a progressive accumulation of fibrillar extracellular matrix (ECM) in the myocardium. The regulation of extracellular matrix remodeling is primarily mediated by cardiac fibroblasts (CF). Evidences suggest that various T lymphocyte phenotypes differentially affect organ fibrosis through modulating CF collagen and MMP/TIMP gene expression, MMP activity and cardiac collagen cross-linking, leading to altered ECM composition. In regard to the importance of cytokines in cardiac fibrosis and heart failure, in this review, we will address the role of different T cell subsets in inflammation-mediated cardiac fibrosis, from a distinct perspective of T cell and fibroblast interaction. We conclude that in addition to preventive strategies, therapies based on deviation of Th1/Th2 paradigm, and manipulation of Tregs and Th17 would show promising results in future studies.

PMID:
20965166
DOI:
10.1016/j.yexmp.2010.10.004
[Indexed for MEDLINE]

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