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Arch Biochem Biophys. 2011 Jan 15;505(2):144-54. doi: 10.1016/j.abb.2010.10.013. Epub 2010 Oct 18.

Troponin T isoforms and posttranscriptional modifications: Evolution, regulation and function.

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1
Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA.

Abstract

Troponin-mediated Ca²(+)-regulation governs the actin-activated myosin motor function which powers striated (skeletal and cardiac) muscle contraction. This review focuses on the structure-function relationship of troponin T, one of the three protein subunits of the troponin complex. Molecular evolution, gene regulation, alternative RNA splicing, and posttranslational modifications of troponin T isoforms in skeletal and cardiac muscles are summarized with emphases on recent research progresses. The physiological and pathophysiological significances of the structural diversity and regulation of troponin T are discussed for impacts on striated muscle function and adaptation in health and diseases.

PMID:
20965144
PMCID:
PMC3018564
DOI:
10.1016/j.abb.2010.10.013
[Indexed for MEDLINE]
Free PMC Article

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