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Psychopharmacology (Berl). 1990;102(4):549-50.

Selenium supplementation improves mood in a double-blind crossover trial.

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Department of Psychology, University College, Swansea, Wales, UK.


The possibility that a sub-clinical deficiency of the trace element selenium might exist in a sample of the British population was examined by giving a selenium supplemented for 5 weeks. Using a double-blind crossover design 50 subjects received either a placebo or 100 micrograms selenium on a daily basis. On three occasions they filled in the Profile of Moods state. Mood did not change when taking the placebo, whereas when taking the selenium the subjects reported a substantial improvement after both 2.5 and 5 weeks.

[Indexed for MEDLINE]

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