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Circ J. 2010 Nov;74(11):2249-56. Epub 2010 Oct 15.

Cyclophilin A: promising new target in cardiovascular therapy.

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Aab Cardiovascular Research Institute and Department of Medicine, University of Rochester School of Medicine and Dentistry.


Cyclophilin A (CyPA) has been studied as a multifunctional protein that is upregulated in a variety of inflammatory conditions, such as rheumatoid arthritis, autoimmune disease, and cancer. CyPA has been classified as an immunophilin and has a variety of intracellular functions, including intracellular signaling, protein trafficking, and the regulation of other proteins activity. Besides its intracellular functions, CyPA is a secreted molecule that has a physiological and pathological role in cardiovascular diseases, making it a potential biomarker and mediator in cardiovascular diseases, such as vascular stenosis, atherosclerosis, and abdominal aortic aneurysms.

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