Format

Send to

Choose Destination
Heart. 2010 Dec;96(23):1883-4. doi: 10.1136/hrt.2010.205534. Epub 2010 Oct 20.

Control of free fatty acids during acute myocardial ischaemia.

Author information

1
University of Edinburgh, UK. michaeloliver@mac.com

Abstract

During the onset of an acute coronary syndrome, an immediate increase in plasma free fatty acid (FFA) concentrations presents the ischaemic underperfused myocardium with a metabolic challenge to its survival. For the maintenance of contraction and to counter ventricular arrhythmias, parenteral treatment to reduce FFA availability should be available for paramedics when the patient is first seen. The best treatment options are insulin which partly inhibits FFA release from adipose tissue, immediate reduction of adipose tissue lipolysis, perhaps by new analogues of nicotinic acid, or measures to decrease the FFA/molar binding ratio with albumin. None has yet been tested in appropriate clinical trials.

PMID:
20962339
DOI:
10.1136/hrt.2010.205534
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center