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Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19163-6. doi: 10.1073/pnas.1006888107. Epub 2010 Oct 20.

High-throughput injection with microfluidics using picoinjectors.

Author information

1
School of Engineering and Applied Sciences and Department of Physics, Harvard University, Cambridge, MA 02138, USA.

Abstract

Adding reagents to drops is one of the most important functions in droplet-based microfluidic systems; however, a robust technique to accomplish this does not exist. Here, we introduce the picoinjector, a robust device to add controlled volumes of reagent using electro-microfluidics at kilohertz rates. It can also perform multiple injections for serial and combinatorial additions.

PMID:
20962271
PMCID:
PMC2984161
DOI:
10.1073/pnas.1006888107
[Indexed for MEDLINE]
Free PMC Article

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