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NMR Biomed. 2011 Jun;24(5):452-7. doi: 10.1002/nbm.1610. Epub 2010 Oct 19.

Preliminary observations of increased diffusional kurtosis in human brain following recent cerebral infarction.

Author information

1
Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, NY 10016-3295, USA. jj33@nyu.edu

Abstract

By application of the MRI method of diffusional kurtosis imaging, a substantially increased diffusional kurtosis was observed within the cerebral ischemic lesions of three stroke subjects, 13-26 h following the onset of symptoms. This increase is interpreted as probably reflecting a higher degree of diffusional heterogeneity in the lesions when compared with normal-appearing contralateral tissue. In addition, for two of the subjects with white matter infarcts, the increase had a strong fiber tract orientational dependence. It is proposed that this effect is consistent with a large drop in the intra-axonal diffusivity, possibly related to either axonal varicosities or alterations associated with the endoplasmic reticulum.

PMID:
20960579
PMCID:
PMC3549661
DOI:
10.1002/nbm.1610
[Indexed for MEDLINE]
Free PMC Article

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