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Mol Cell Biochem. 2011 Jan;347(1-2):95-101. doi: 10.1007/s11010-010-0617-0. Epub 2010 Oct 20.

High glucose promotes cell proliferation and enhances GDNF and RET expression in pancreatic cancer cells.

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Department of Hepatobiliary Surgery, First Affiliated Hospital of Xi'an Jiaotong University, 227 West Yan-ta Road, Xi'an, 710061, China.


Hyperglycemia promotes pancreatic cancer progression, while the underlying mechanism is uncertain. We investigated the cell proliferation, glial cell line-derived neurotrophic factor (GDNF) and its tyrosine kinase receptor RET expression in BxPC-3 and MIA PaCa-2 cells when exposed to different concentrations of glucose. Proliferation of both cells was effected by glucose in a concentration-dependent manner. Definite expression of GDNF and RET was detected in both cells. Glucose concentrations could alter the expression of GDNF and RET in a concentration-dependent manner, correspondingly with the alterations of cell proliferation. Up-regulation of GDNF and RET ligand-receptor interaction might participate in the glucose-induced cancer progression.

[Indexed for MEDLINE]

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