Format

Send to

Choose Destination
J Cereb Blood Flow Metab. 2011 Jan;31(1):41-6. doi: 10.1038/jcbfm.2010.186. Epub 2010 Oct 20.

External globus pallidus stimulation modulates brain connectivity in Huntington's disease.

Author information

1
Laboratoire de Cartographie Fonctionnelle du Cerveau, ULB-Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. nligot@ulb.ac.be

Abstract

Positron emission tomography with O-15-labeled water was used to study at rest the neurophysiological effects of bilateral external globus pallidus (GPe) deep brain stimulation in patients with Huntington's disease (HD). Five patients were compared with a control group in the on and off states of the stimulator. External globus pallidus stimulation decreased neuronal activity and modulated cerebral connectivity within the basal ganglia-thalamocortical circuitry, the sensorimotor, and the default-mode networks. These data indicate that GPe stimulation modulates functional integration in HD patients in accordance with the basal ganglia-thalamocortical circuit model.

PMID:
20959850
PMCID:
PMC3049470
DOI:
10.1038/jcbfm.2010.186
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center