Format

Send to

Choose Destination
Heart. 2010 Nov;96(22):1821-5. doi: 10.1136/hrt.2010.195412. Epub 2010 Oct 19.

Low serum testosterone and increased mortality in men with coronary heart disease.

Author information

1
Department of Cardiology, Royal Hallamshire Hospital, Sheffield, UK

Abstract

BACKGROUND:

To examine the effect of serum testosterone levels on survival in a consecutive series of men with confirmed coronary disease and calculate the prevalence of testosterone deficiency.

DESIGN:

Longitudinal follow-up study.

SETTING:

Tertiary referral cardiothoracic centre. Patients 930 consecutive men with coronary disease referred for diagnostic angiography recruited between June 2000 and June 2002 and followed up for a mean of 6.9±2.1 years.

OUTCOME:

All-cause mortality and vascular mortality. Prevalence of testosterone deficiency.

RESULTS:

The overall prevalence of biochemical testosterone deficiency in the coronary disease cohort using bio-available testosterone (bio-T) <2.6 nmol/l was 20.9%, using total testosterone <8.1 nmol/l was 16.9% and using either was 24%. Excess mortality was noted in the androgen-deficient group compared with normal (41 (21%) vs 88 (12%), p=0.002). The only parameters found to influence time to all-cause and vascular mortality (HR ± 95% CI) in multivariate analyses were the presence of left ventricular dysfunction (3.85; 1.72 to 8.33), aspirin therapy (0.63; 0.38 to 1.0), β-blocker therapy (0.45; 0.31 to 0.67) and low serum bio-T (2.27; 1.45 to 3.6).

CONCLUSIONS:

In patients with coronary disease testosterone deficiency is common and impacts significantly negatively on survival. Prospective trials of testosterone replacement are needed to assess the effect of treatment on survival.

PMID:
20959649
DOI:
10.1136/hrt.2010.195412
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for HighWire
Loading ...
Support Center