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Br J Radiol. 2011 Jan;84(997):44-50. doi: 10.1259/bjr/59381313. Epub 2010 Oct 19.

Dobutamine stress tagging and gradient-echo imaging for detection of coronary heart disease at 3 T.

Author information

1
Department of Radiology, University of Bonn, Germany. daniel.thomas@ukb.uni-bonn.de

Abstract

OBJECTIVE:

The purpose of this study was to evaluate the feasibility and diagnostic accuracy of a combined spoiled gradient-echo (sGRE) and tagged gradient-echo (SPAMM-GRE) protocol for detection of coronary artery disease (CAD) during high-dose dobutamine stress at 3 T.

METHOD:

The study protocol was approved by the local ethics committee. For stress testing, a standard high-dose dobutamine protocol was employed. Image quality at the highest stress level and diagnostic accuracy of the sGRE and SPAMM-GRE sequences were compared. The final study population consisted of 37 patients.

RESULTS:

The mean image quality score was 2.6±0.6 for the sGRE sequence and 2.4±0.6 for the SPAMM-GRE sequence (p>0.05). Sensitivity, specificity and diagnostic accuracy were 0.81, 0.86, 0.84 and 0.88, 0.86, 0.86 for the sGRE and SPAMM-GRE, respectively. In three cases with new wall motion abnormalities (WMAs), detected by sGRE and SPAMM-GRE, WMAs were detected at a lower stress level by tagging.

CONCLUSION:

The combined sGRE and SPAMM-GRE high-dose dobutamine protocol at 3 T is feasible and delivers good diagnostic accuracy. Tagging increases the sensitivity of high-dose dobutamine stress testing for detection of CAD and may allow for detection of new WMAs at lower stress levels compared with sGRE alone.

PMID:
20959376
PMCID:
PMC3473814
DOI:
10.1259/bjr/59381313
[Indexed for MEDLINE]
Free PMC Article
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