Neurobehavioral screening in rodents

Curr Protoc Toxicol. 2001 May:Chapter 11:Unit11.2. doi: 10.1002/0471140856.tx1102s06.

Abstract

Neurobehavioral evaluations are an important component of screening for neurotoxicological effects. A neurobehavioral test battery is chosen to assess a variety of endpoints, including autonomic, neuromuscular, sensory, and excitability functions. Such a battery includes observation of gait and posture, reactivity and arousal, gait and postural characteristics, involuntary/abnormal motor movements, clinical signs and manipulation of neurological reflexes and reactions and neuromuscular activity and postural reactions. Finally, the battery includes assessment of sensory responses.

MeSH terms

  • Animals
  • Behavior, Animal / drug effects*
  • Dose-Response Relationship, Drug
  • Drug Evaluation, Preclinical
  • Gait / drug effects
  • Motor Activity / drug effects
  • Nervous System Diseases / chemically induced*
  • Nervous System Diseases / physiopathology
  • Nervous System Diseases / psychology
  • Neurologic Examination
  • Neuropsychological Tests*
  • Posture
  • Psychomotor Performance / drug effects
  • Rodentia
  • Toxicity Tests / methods*