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Int J Mol Sci. 2010 Sep 15;11(9):3298-322. doi: 10.3390/ijms11093298.

Materials for pharmaceutical dosage forms: molecular pharmaceutics and controlled release drug delivery aspects.

Author information

1
Division of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA; E-Mails: minjisohn@uky.edu (M.S.); amalg0@email.uky.edu (A.A.-G.); ppdelu1@email.uky.edu (P.P.D).

Abstract

Controlled release delivery is available for many routes of administration and offers many advantages (as microparticles and nanoparticles) over immediate release delivery. These advantages include reduced dosing frequency, better therapeutic control, fewer side effects, and, consequently, these dosage forms are well accepted by patients. Advances in polymer material science, particle engineering design, manufacture, and nanotechnology have led the way to the introduction of several marketed controlled release products and several more are in pre-clinical and clinical development.

KEYWORDS:

biodegradable; biomaterials; copolymers; manufacture; microparticle; nanoparticle; particle engineering design; pharmaceutical dosage forms; polymers

PMID:
20957095
PMCID:
PMC2956096
DOI:
10.3390/ijms11093298
[Indexed for MEDLINE]
Free PMC Article

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