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Antimicrob Agents Chemother. 2011 Jan;55(1):417-20. doi: 10.1128/AAC.01080-10. Epub 2010 Oct 18.

Short alkylated peptoid mimics of antimicrobial lipopeptides.

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1
Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, USA.

Abstract

We report the creation of alkylated poly-N-substituted glycine (peptoid) mimics of antimicrobial lipopeptides with alkyl tails ranging from 5 to 13 carbons. In several cases, alkylation significantly improved the selectivity of the peptoids with no loss in antimicrobial potency. Using this technique, we synthesized an antimicrobial peptoid only 5 monomers in length with selective, broad-spectrum antimicrobial activity as potent as previously reported dodecameric peptoids and the antimicrobial peptide pexiganan.

PMID:
20956607
PMCID:
PMC3019626
DOI:
10.1128/AAC.01080-10
[Indexed for MEDLINE]
Free PMC Article
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