Format

Send to

Choose Destination
See comment in PubMed Commons below
Neuron. 2010 Oct 21;68(2):282-92. doi: 10.1016/j.neuron.2010.10.008.

Episodic neurological channelopathies.

Author information

1
Neuroscience Graduate Program, University of California-San Francisco, San Francisco, CA 94158, USA.

Abstract

Inherited episodic neurological disorders are often due to mutations in ion channels or their interacting proteins, termed channelopathies. There are a wide variety of such disorders, from those causing paralysis, to extreme pain, to ataxia. A common theme in these is alteration of action potential properties or synaptic transmission and a resulting increased propensity of the resulting tissue to enter into or stay in an altered excitability state. Manifestations of these disorders are triggered by an array of precipitants, all of which stress the particular affected tissue in some way and aid in propelling its activity into an aberrant state. Study of these disorders has aided in the understanding of disease risk factors and elucidated the cause of clinically related sporadic disorders. The findings from study of these disorders will aid in the diagnosis and efficient targeted treatment of affected patients.

PMID:
20955935
DOI:
10.1016/j.neuron.2010.10.008
[Indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center