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Neuron. 2010 Oct 21;68(2):201-6. doi: 10.1016/j.neuron.2010.10.014.

Genetic analysis of pathways to Parkinson disease.

Author information

1
Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK. j.hardy@ion.ucl.ac.uk

Abstract

In this review I outline the arguments as to whether we should consider Parkinson disease one or more than one entity and discuss genetic findings from Mendelian and whole-genome association analysis in that context. I discuss what the demonstration of disease spread implies for our analysis of the genetic and epidemiologic risk factors for disease and outline the surprising fact that we now have genetically identified on the order of half our risk for developing the disease.

PMID:
20955928
PMCID:
PMC2997424
DOI:
10.1016/j.neuron.2010.10.014
[Indexed for MEDLINE]
Free PMC Article

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