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Expert Opin Biol Ther. 2010 Nov;10(11):1539-53. doi: 10.1517/14712598.2010.526105.

Genetically modified dendritic cells in cancer immunotherapy: a better tomorrow?

Author information

1
Department of Pathology and Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Abstract

IMPORTANCE OF THE FIELD:

Dendritic cells (DC) are powerful antigen-presenting cells that induce and maintain primary cytotoxic T lymphocyte (CTL) responses directed against tumor antigens. Consequently, there has been much interest in their application as antitumor vaccines.

AREAS COVERED IN THIS REVIEW:

A large number of DC-based vaccine trials targeting a variety of cancers have been conducted; however, the rate of reported clinically significant responses remains low. Modification of DC to express tumor antigens or immunostimulatory molecules through the transfer of genes or mRNA transfection offers a logical alternative with potential advantages over peptide- or protein antigen-loaded DC. In this article, we review the current results and future prospects for genetically modified DC vaccines for the treatment of cancer.

WHAT THE READER WILL GAIN:

Genetically-modified dendritic cell-based vaccines represent a powerful tool for cancer therapy. Numerous preclinical and clinical studies have demonstrated the potential of dendritic cell vaccines alone or in combination with other therapeutic modalities.

TAKE HOME MESSAGE:

Genetically modified DC-based anti-cancer vaccination holds promise, perhaps being best employed in the adjuvant setting with minimal residual disease after primary therapy, or in combination with other antitumor or immune-enhancing therapies.

PMID:
20955111
DOI:
10.1517/14712598.2010.526105
[Indexed for MEDLINE]
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