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Health Psychol. 2010 Nov;29(6):626-35. doi: 10.1037/a0021360.

Socioeconomic and psychosocial predictors of interleukin-6 in the MIDUS national sample.

Author information

1
Department of Psychology, University of Wisconsin-Madison, Madison, WI 53706, USA. morozink@wisc.edu

Abstract

OBJECTIVE:

To investigate whether psychosocial factors (i.e., depression, anxiety, and well-being) moderated educational gradients in interleukin-6 (IL-6) levels using data from the Survey of Midlife Development in the U.S. (MIDUS). The influences of educational attainment and psychosocial factors on IL-6 in middle aged and older adults were also examined.

DESIGN:

Telephone interviews and mail surveys were utilized to collect educational attainment and psychosocial information from respondents (N = 1028). Respondents also participated in an overnight clinic visit, during which health information and a fasting blood sample were obtained.

MAIN OUTCOME MEASURES:

Serum levels of IL-6.

RESULTS:

Greater educational attainment predicted lower levels of IL-6 independent of age and gender, although this effect was attenuated after taking health behaviors, body mass index, waist-to-hip ratio, and chronic illnesses into account. Psychological well-being interacted with education to predict IL-6, such that for those with less education, higher well-being was associated with lower levels of IL-6.

CONCLUSION:

The findings indicate a strong association between education and inflammation, which can be further moderated by psychosocial factors. The health benefits associated with psychological well-being were particularly evident for individuals with low educational attainment.

PMID:
20954777
PMCID:
PMC2991411
DOI:
10.1037/a0021360
[Indexed for MEDLINE]
Free PMC Article

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