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Diabetologia. 2011 Jan;54(1):87-92. doi: 10.1007/s00125-010-1925-3. Epub 2010 Oct 17.

Association of exposure to diabetes in utero with adiposity and fat distribution in a multiethnic population of youth: the Exploring Perinatal Outcomes among Children (EPOCH) Study.

Author information

1
Department of Epidemiology, University of Colorado Denver, Aurora, 80045, USA.

Abstract

AIMS/HYPOTHESIS:

To evaluate whether exposure to maternal gestational diabetes (GDM) is associated with adiposity and fat distribution in a multiethnic population of children.

METHODS:

Retrospective cohort study of 82 children exposed to maternal GDM and 379 unexposed youths 6-13 years of age with measured BMI, waist circumference, skinfold thickness, and visceral and subcutaneous abdominal fat.

RESULTS:

Exposure to maternal GDM was associated with higher BMI (p = 0.02), larger waist circumference (p = 0.004), more subcutaneous abdominal fat (p = 0.01) and increased subscapular to triceps skinfold thickness ratio (p = 0.01) in models adjusted for age, sex, race/ethnicity and Tanner stage. Adjustment for socioeconomic factors, birthweight and gestational age, maternal smoking during pregnancy and current diet and physical activity did not influence associations; however, adjustment for maternal pre-pregnancy BMI attenuated all associations.

CONCLUSIONS/INTERPRETATION:

Exposure to maternal GDM is associated with increased overall and abdominal adiposity, and a more central fat distribution pattern in 6- to 13-year-old youths from a multi-ethnic population, providing further support for the fetal overnutrition hypothesis.

PMID:
20953862
PMCID:
PMC3027214
DOI:
10.1007/s00125-010-1925-3
[Indexed for MEDLINE]
Free PMC Article

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