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Nat Neurosci. 2010 Nov;13(11):1413-20. doi: 10.1038/nn.2659. Epub 2010 Oct 17.

The functional asymmetry of auditory cortex is reflected in the organization of local cortical circuits.

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1
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.

Abstract

The primary auditory cortex (A1) is organized tonotopically, with neurons sensitive to high and low frequencies arranged in a rostro-caudal gradient. We used laser scanning photostimulation in acute slices to study the organization of local excitatory connections onto layers 2 and 3 (L2/3) of the mouse A1. Consistent with the organization of other cortical regions, synaptic inputs along the isofrequency axis (orthogonal to the tonotopic axis) arose predominantly within a column. By contrast, we found that local connections along the tonotopic axis differed from those along the isofrequency axis: some input pathways to L3 (but not L2) arose predominantly out-of-column. In vivo cell-attached recordings revealed differences between the sound-responsiveness of neurons in L2 and L3. Our results are consistent with the hypothesis that auditory cortical microcircuitry is specialized to the one-dimensional representation of frequency in the auditory cortex.

PMID:
20953193
PMCID:
PMC3140463
DOI:
10.1038/nn.2659
[Indexed for MEDLINE]
Free PMC Article
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