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Gastroenterol Clin North Am. 2010 Sep;39(3):529-42. doi: 10.1016/j.gtc.2010.08.009.

The safety of drugs used in acid-related disorders and functional gastrointestinal disorders.

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1
Division of Gastroenterology, Northwestern University Feinberg School of Medicine, 676 North Saint Clair Street, Suite 1400, Chicago, IL 60611, USA.

Abstract

Medicines are frequently used in the management of acid-related disorders and functional gastrointestinal disorders. With the exception of complicated peptic ulcer disease, these disorders are not associated with appreciable mortality. Drug treatments have consequently been held to the highest standards of safety. Some medicines have been withdrawn or restricted based on assessments and perceptions of risk. However, the risk of serious toxicity is low for most of the agents discussed in this article. Assessments are made of the safety and adverse-event profiles of certain drug classes and, where appropriate, individual medicines. For conditions with a low risk of mortality or serious morbidity, clinicians need to balance the risks of potential adverse events with the anticipated benefits of a successful outcome of specific drug treatment.

PMID:
20951916
PMCID:
PMC3117659
DOI:
10.1016/j.gtc.2010.08.009
[Indexed for MEDLINE]
Free PMC Article
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