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Trends Microbiol. 2010 Dec;18(12):561-8. doi: 10.1016/j.tim.2010.09.002. Epub 2010 Oct 15.

Unraveling type III secretion systems in the highly versatile Burkholderia pseudomallei.

Author information

1
Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8, Medical Drive, Singapore 117597.

Abstract

Burkholderia pseudomallei is a highly versatile pathogen capable of infecting many species of animals and plants. It is the causative agent of melioidosis, a medically important infectious disease in humans with a wide spectrum of disease manifestations. Its versatility as a pathogen is reflected in its huge 7.2Mb genome and the many virulence mechanisms it possesses, including three different type III secretion systems (T3SSs). Recent elucidation of the regulatory network of T3SS3 and the characterization of several T3SS proteins have enabled us to construct a model of the B. pseudomallei T3SS3 apparatus and evaluate the role it plays in disease pathogenesis.

PMID:
20951592
DOI:
10.1016/j.tim.2010.09.002
[Indexed for MEDLINE]

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