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Microbes Infect. 2011 Jan;13(1):96-102. doi: 10.1016/j.micinf.2010.10.002. Epub 2010 Oct 14.

Migratory responses of leukocytes infected with Toxoplasma gondii.

Author information

1
Center for Infectious Medicine, Department. of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden. henrik.lambert@ki.se

Abstract

Recently, monocytic cells were suggested to systemically transport Toxoplasma tachyzoites during acute infection in mice. The mechanism underlying this shuttling function may partly be explained by dramatically enhanced host-cell motility upon parasite invasion. Here, we report that infection of human and murine macrophages in vitro resulted in augmented migration across a transwell membrane, linked to host-cell differentiation and to the parasite genotype. The hypermotility phenotype was absent in infected monocytes, NK, B or T-cells. In contrast to previous observations with dendritic cells, adoptive transfer of infected macrophages or lymphocytes did not exacerbate infection in mice compared to inoculation with free parasites.

PMID:
20951223
DOI:
10.1016/j.micinf.2010.10.002
[Indexed for MEDLINE]

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