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Pediatr Nephrol. 2011 Apr;26(4):523-33. doi: 10.1007/s00467-010-1637-4. Epub 2010 Oct 15.

Advances in our understanding of the pathogenesis of glomerular thrombotic microangiopathy.

Author information

1
Department of Medical Pediatrics, Royal Hospital for Sick Children, Yorkhill, Glasgow, UK.

Abstract

Glomerular thrombotic microangiopathy is a hallmark feature of haemolytic uraemic syndrome, the leading cause of acute renal failure in childhood. This paper is a review of the different mechanistic pathways that lead to this histological picture in the kidney. It will focus on atypical HUS and complement dysregulation, but will also highlight some other recent advances in our understanding of this condition, including the potential role of the molecule vascular endothelial growth factor-A (VEGF-A).

PMID:
20949284
PMCID:
PMC3043262
DOI:
10.1007/s00467-010-1637-4
[Indexed for MEDLINE]
Free PMC Article

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