Format

Send to

Choose Destination
See comment in PubMed Commons below
Mar Drugs. 2010 Sep 15;8(9):2493-516. doi: 10.3390/md8092493.

N-acetylglucosamine: production and applications.

Author information

1
Department of Environment and Biotechnology, Refining & Manufacturing Research Institute, CPC Corporation, 217 Min-Sheng S. Rd, Chiayi, Taiwan.

Abstract

N-Acetylglucosamine (GlcNAc) is a monosaccharide that usually polymerizes linearly through (1,4)-β-linkages. GlcNAc is the monomeric unit of the polymer chitin, the second most abundant carbohydrate after cellulose. In addition to serving as a component of this homogeneous polysaccharide, GlcNAc is also a basic component of hyaluronic acid and keratin sulfate on the cell surface. In this review, we discuss the industrial production of GlcNAc, using chitin as a substrate, by chemical, enzymatic and biotransformation methods. Also, newly developed methods to obtain GlcNAc using glucose as a substrate in genetically modified microorganisms are introduced. Moreover, GlcNAc has generated interest not only as an underutilized resource but also as a new functional material with high potential in various fields. Here we also take a closer look at the current applications of GlcNAc, and several new and cutting edge approaches in this fascinating area are thoroughly discussed.

KEYWORDS:

N-acetylglucosamine; carbohydrate; chitin

PMID:
20948902
PMCID:
PMC2953398
DOI:
10.3390/md8092493
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for PubMed Central
    Loading ...
    Support Center