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F1000 Biol Rep. 2010 Jul 14;2. pii: 50. doi: 10.3410/B2-50.

Hidden ribozymes in eukaryotic genome sequence.

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Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School 364 Plantation Street, LRB-906, Worcester, MA 01605 USA.


The small self-cleaving ribozymes fold into complex tertiary structures to promote autocatalytic cleavage or ligation at a precise position within their sequence. Until recently, relatively few examples had been identified. Two papers now reveal that self-cleaving ribozymes are prevalent in eukaryotic genomes and, in some cases, might play a role in regulating gene expression.

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