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Nat Med. 2010 Nov;16(11):1241-7. doi: 10.1038/nm.2230. Epub 2010 Oct 14.

Overcoming obstacles to developing new analgesics.

Author information

1
Neurobiology Center and Program in Neurobiology, Department of Neurology, Children's Hospital Boston, Boston, Massachusetts, USA. clifford.woolf@childrens.harvard.edu

Abstract

Despite substantial investment by the pharmaceutical industry over several decades, there has been little progress in developing new, efficacious and safe analgesics. As a result, many large pharmaceutical companies are leaving the area of pain medication. Nevertheless, the chances of success could increase if analgesic drug development strategy changed. To achieve such a paradigm shift we must understand why development of drugs for pain relief is so challenging.

PMID:
20948534
DOI:
10.1038/nm.2230
[Indexed for MEDLINE]

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