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Cell Cycle. 2010 Oct 15;9(20):4061-7. Epub 2010 Oct 10.

Taking apart Rap1: an adaptor protein with telomeric and non-telomeric functions.

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1
Laboratory for Cell Biology and Genetics, The Rockefeller University, New York, NY, USA.

Abstract

Mammalian Rap1, a TRF2-interacting protein in the telomeric shelterin complex, was recently shown to repress homology-directed repair at chromosome ends. In addition, Rap1 plays a role in transcriptional regulation and NFκB signaling. Rap1 is unique among the components of shelterin in that it is conserved in budding yeast and has non-telomeric functions. Comparison of mammalian Rap1 to the Rap1 proteins of several budding yeasts and fission yeast reveal both striking similarities and notable differences. The protean nature of Rap1 is best understood by viewing it as an adaptor that can mediate a variety of protein-protein and protein-DNA interactions depending on the organism and the complex in which it is functioning.

PMID:
20948311
PMCID:
PMC2995270
DOI:
10.4161/cc.9.20.13579
[Indexed for MEDLINE]
Free PMC Article

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