This article considers common minimally invasive craniotomy approaches and the role of neuroendoscopy in the removal of extra-axial and intra-axial brain tumors, excluding those of the ventricle. The use of a keyhole craniotomy combined with a carefully selected trajectory can help avoid the disadvantages associated with a standard craniotomy. However, the decision to use endoscopy must be individualized based on the patient and tumor. Endoscopy can also be used as a surgical adjunct to improve tumor resection and to help protect neurovascular structures. Complications associated with minimally invasive tumor neurosurgery have been similar to those associated with conventional neurosurgical approaches, and available outcomes are promising.
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