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Cell. 2010 Oct 15;143(2):184-6. doi: 10.1016/j.cell.2010.09.046.

The Myc connection: ES cells and cancer.

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Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Palo Alto, CA 94305, USA.

Abstract

Gene profiling experiments have revealed similarities between cancer and embryonic stem (ES) cells. Kim et al. (2010) dissect the gene expression signature of ES cells into three functional modules and find that the Myc module, including genes targeted by Myc-interacting proteins, accounts for most of the similarity between ES and cancer cells.

PMID:
20946977
DOI:
10.1016/j.cell.2010.09.046
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