Send to

Choose Destination
See comment in PubMed Commons below
Nutr Rev. 2010 Nov;68 Suppl 1:S16-21. doi: 10.1111/j.1753-4887.2010.00330.x.

Design considerations in long-term intervention studies for the prevention of cognitive decline or dementia.

Author information

Department of Nutrition and Public Health Intervention Research, London School of Hygiene & Tropical Medicine, London, United Kingdom.


The results of randomized controlled trials of nutritional interventions aimed at preventing cognitive decline or dementia in older people have been largely disappointing. A reasonable argument can be made that this is at least in part because the design of primary prevention trials in older people is not straightforward and that the complexities of such trials are not readily apparent and commonly remain not fully recognized. This article analyzes some of the difficulties associated with identifying and enrolling study participants in long-term prevention trials, with available data from three large, recently published trials used as examples. This analysis also serves to identify examples of good practice and areas for further research. Randomized controlled trials remain the single most important tool in the epidemiological arsenal for identifying the effects of specific interventions, but consideration of critically important design features is essential.

[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems
    Loading ...
    Support Center