Send to

Choose Destination
See comment in PubMed Commons below
Anim Genet. 2011 Apr;42(2):191-203. doi: 10.1111/j.1365-2052.2010.02110.x. Epub 2010 Oct 14.

Quantitative trait loci for resistance to fish pasteurellosis in gilthead sea bream (Sparus aurata).

Author information

  • 1Division of Genetics and Genomics, Roslin Institute and Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Roslin, Midlothian, EH25 9PS, UKAnimal Breeding and Genomic Centre, Wageningen University, PO Box 338, NL-6700AH, Wageningen, The NetherlandsDepartment of Public Health, Comparative Pathology, and Veterinary Hygiene University of Padova, Viale dell'Universit√† 16, Agripolis, I-35020 Legnaro, ItalyMRC Human Genetics Unit, Western General Hospital, Crewe Road, Edinburgh, EH4 2XU, UK.


Fish pasteurellosis is a bacterial disease causing important losses in farmed fish, including gilthead sea bream, a teleost fish of great relevance in marine aquaculture. We report in this study a QTL analysis for resistance to fish pasteurellosis in this species. An experimental population of 500 offspring originating from eight sires and six dams in a single mass-spawning event was subjected to a disease challenge with Photobacterium damselae subsp. piscicida (Phdp), the causative agent of fish pasteurellosis. A total of 151 microsatellite loci were genotyped in the experimental population, and half-sib regression QTL analysis was carried out on two continuous traits, body length at time of death and survival, and for two binary traits, survival at day 7 and survival at day 15, when the highest peaks of mortality were observed. Two significant QTLs were detected for disease resistance. The first one was located on linkage group LG3 affecting late survival (survival at day 15). The second one, for overall survival, was located on LG21, which allowed us to highlight a potential marker (Id13) linked to disease resistance. A significant QTL was also found for body length at death on LG6 explaining 5-8% of the phenotypic variation.


Photobacterium damselae piscicida; QTL; Sparus aurata; body length; disease resistance; gilthead sea bream; pasteurellosis

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Wiley
    Loading ...
    Support Center