Send to

Choose Destination
See comment in PubMed Commons below
J Invest Dermatol. 2010 Nov;130(11):2540-2. doi: 10.1038/jid.2010.295.

IL-17: important for host defense, autoimmunity, and allergy?

Author information

  • 1Division of Pulmonary and Critical Care Medicine, University of Rochester Medical Center, Rochester, New York, USA.


In this issue, Milovanovic and colleagues present evidence that IL-17a enhances IgE production, although the precise mechanism remains unclear. Their initial finding was that higher numbers of IL-17a-producing CD4(+) T cells were observed after polyclonal stimulation in a largely airway allergic population. These data add to the evidence that atopic disorders such as asthma and, possibly, atopic dermatitis (AD) may have distinct immunologic phenotypes. The hope is that by characterizing the immunologic basis of these common diseases we will be able to understand the heterogeneity observed in natural history, response to treatments, susceptibility to infections, genetic risk factors, and associations with other atopic disorders.

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center