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J Gen Virol. 2011 Jan;92(Pt 1):18-30. doi: 10.1099/vir.0.025593-0. Epub 2010 Oct 13.

Keep it in the subfamily: the conserved alphaherpesvirus US3 protein kinase.

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Department of Virology, Parasitology, and Immunology, Faculty of Veterinary Medicine, Ghent University, Belgium.


The US3 protein kinase is conserved over the alphaherpesvirus subfamily. Increasing evidence shows that, although the kinase is generally not required for virus replication in cell culture, it plays a pivotal and in some cases an essential role in virus virulence in vivo. The US3 protein is a multifunctional serine/threonine kinase that is involved in viral gene expression, virion morphogenesis, remodelling the actin cytoskeleton and the evasion of several antiviral host responses. In the current review, both the well conserved and virus-specific functions of alphaherpesvirus US3 protein kinase orthologues will be discussed.

[Indexed for MEDLINE]

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