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Ann Oncol. 2011 Mar;22(3):536-44. doi: 10.1093/annonc/mdq603. Epub 2010 Oct 13.

Coffee and cancers of the upper digestive and respiratory tracts: meta-analyses of observational studies.

Author information

1
Department of Epidemiology, Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy.

Abstract

BACKGROUND:

Data of epidemiological studies on the relation between coffee drinking and upper aerodigestive tract cancer risk are scattered and inconclusive. We therefore conducted systematic meta-analyses of observational studies published before October 2009.

MATERIALS AND METHODS:

We combined relative risks (RR) with 95% confidence intervals (CI) for cancers of the oral cavity/pharynx (OP) and larynx, esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC), comparing the highest versus the lowest categories of coffee consumption, using random-effects models.

RESULTS:

For OP cancer, the pooled RR was 0.64 (95% CI 0.51-0.80) for highest versus lowest coffee drinking, based on a total of 2633 cases from one cohort and eight case-control studies, with no significant heterogeneity across studies. The RRs were 0.61 (95% CI 0.41-0.89) for European, 0.58 (95% CI 0.36-0.94) for American and 0.74 (95% CI 0.48-1.15) for Asian studies, where coffee consumption is lower. The corresponding RRs were 1.56 (95% CI 0.60-4.02) for laryngeal cancer (732 cases from three case-control studies), 0.87 (95% CI 0.65-1.17) for ESCC (2115 cases from one cohort and six case-control studies) and 1.18 (95% CI 0.81-1.71) for EAC (415 cases from three case-control studies).

CONCLUSION:

Coffee drinking is inversely related to OP cancer risk, while there is no relation with laryngeal cancer, ESCC and EAC.

PMID:
20943597
DOI:
10.1093/annonc/mdq603
[Indexed for MEDLINE]

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