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Curr Opin Microbiol. 2010 Dec;13(6):730-7. doi: 10.1016/j.mib.2010.09.015. Epub 2010 Oct 11.

Advances in understanding E. coli cell fission.

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Department of Molecular Biology and Microbiology, Case Western Reserve University, School of Medicine, W213, 10900 Euclid Ave, Cleveland, OH 44106, USA.


Much of what we know about cytokinesis in bacteria has come from studies with Escherichia coli, and efforts to comprehensively understand this fundamental process in this organism continue to intensify. Major recent advances include in vitro assembly of a membrane-tethered version of FtsZ into contractile rings in lipid tubules, in vitro dynamic patterning of the Min proteins and a deeper understanding of how they direct assembly of the FtsZ-ring to midcell, the elucidation of structures, biochemical activities and interactions of other key components of the cell fission machinery, and the uncovering of additional components of this machinery with often redundant but important roles in invagination of the three cell envelope layers.

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