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Int J Immunopathol Pharmacol. 2010 Jul-Sep;23(3):709-13.

IL-31 a Th2 cytokine involved in immunity and inflammation.

Abstract

Cytokines are immunal regulatory proteins, however they also play a relevant role in inflammatory diseases. IL-31 is a newly discovered cytokine expressed primarily in TH2 cells, introduced by activated CD4+ T cells. IL-31 is capable of inducing chemokines and other cytokines in several inflammatory diseases via its surface receptor. This cytokine is also produced by mast cells and mast cell line, suggesting a role in allergic diseases. In this editorial we revisit the biological role of IL-31 in immunity and inflammation.

PMID:
20943040
DOI:
10.1177/039463201002300304
[Indexed for MEDLINE]
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