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Biomacromolecules. 2010 Nov 8;11(11):2845-53. doi: 10.1021/bm100526a. Epub 2010 Oct 13.

Development of electrically conductive oligo(polyethylene glycol) fumarate-polypyrrole hydrogels for nerve regeneration.

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1
Departments of Orthopedic Surgery, Biomedical Engineering, and Neurology, Mayo Clinic College of Medicine, 200 First Street SW, MS 3-69, Rochester, Minnesota 55905, and Central Microscopy Research Facility, University of Iowa, Iowa City, Iowa 52243.

Abstract

Electrically conductive hydrogel composites consisting of oligo(polyethylene glycol) fumarate (OPF) and polypyrrole (PPy) were developed for applications in nerve regeneration. OPF-PPy scaffolds were synthesized using three different anions: naphthalene-2-sulfonic acid sodium salt (NSA), dodecylbenzenesulfonic acid sodium salt (DBSA), and dioctyl sulfosuccinate sodium salt (DOSS). Scaffolds were characterized by ATR-FTIR, XPS, AFM, dynamic mechanical analysis, electrical resistivity measurements, and swelling experiments. OPF-PPy scaffolds were shown to consist of up to 25 mol % polypyrrole with a compressive modulus ranging from 265 to 323 kPa and a sheet resistance ranging from 6 to 30 × 10(3) Ohms/square. In vitro studies using PC12 cells showed OPF-PPy materials had no cytotoxicity and PC12 cells showed distinctly better cell attachment and an increase in the percent of neurite bearing cells on OPF-PPy materials compared to OPF. The neurite lengths of PC12 cells were significantly higher on OPF-PPyNSA and OPF-PPyDBSA. These results show that electrically conductive OPF-PPy hydrogels are promising candidates for future applications in nerve regeneration.

PMID:
20942380
PMCID:
PMC3947846
DOI:
10.1021/bm100526a
[Indexed for MEDLINE]
Free PMC Article
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