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Nat Rev Genet. 2010 Nov;11(11):761-72. doi: 10.1038/nrg2901. Epub 2010 Oct 13.

The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation.

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1
Laboratory of Biochemistry and Molecular Biology, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA. maliks@rockefeller.edu

Abstract

The Mediator is an evolutionarily conserved, multiprotein complex that is a key regulator of protein-coding genes. In metazoan cells, multiple pathways that are responsible for homeostasis, cell growth and differentiation converge on the Mediator through transcriptional activators and repressors that target one or more of the almost 30 subunits of this complex. Besides interacting directly with RNA polymerase II, Mediator has multiple functions and can interact with and coordinate the action of numerous other co-activators and co-repressors, including those acting at the level of chromatin. These interactions ultimately allow the Mediator to deliver outputs that range from maximal activation of genes to modulation of basal transcription to long-term epigenetic silencing.

PMID:
20940737
PMCID:
PMC3217725
DOI:
10.1038/nrg2901
[Indexed for MEDLINE]
Free PMC Article
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