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Am J Hypertens. 2011 Jan;24(1):90-5. doi: 10.1038/ajh.2010.193. Epub 2010 Sep 9.

Arterial stiffness and gait speed in older adults with and without peripheral arterial disease.

Author information

1
Department of Epidemiology, University of Pittsburgh, Pennsylvania, USA. norawatson@gmail.com

Erratum in

  • Am J Hypertens. 2011 Feb;24(2):248. Nemwan, Anne B [corrected to Newman, Anne B].

Abstract

BACKGROUND:

Central arterial stiffness is increasingly recognized as an important predictor of cardiovascular events and mortality in older adults; however, few studies have evaluated the association of arterial stiffness with mobility decline, a common consequence of vascular disease.

METHODS:

We analyzed the association of pulse wave velocity (PWV), a measure of aortic stiffness, with longitudinal gait speed over 7 years in 2,172 participants in the Health, Aging and Body Composition (ABC) Study (mean age ± s.d. 73.6 ± 2.9 years, 48% men, 39% black).

RESULTS:

In mixed-effects models adjusted for demographics, each s.d. (396 cm/s) higher PWV was associated with 0.015 (s.e. 0.004) m/s slower gait at baseline and throughout the study period in the full cohort (P < 0.001); this relationship was largely explained by hypertension and other vascular risk factors. Among participants with peripheral arterial disease (PAD) (n = 261; 12.7%), each s.d. higher PWV was independently associated with 0.028 (s.e. 0.010) m/s slower gait speed at baseline and throughout the study period (P < 0.01).

CONCLUSIONS:

These findings suggest that aortic stiffness may be especially detrimental to mobility in older adults with already compromised arterial function.

PMID:
20940711
PMCID:
PMC3290653
DOI:
10.1038/ajh.2010.193
[Indexed for MEDLINE]
Free PMC Article
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